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result sql = Evaluation of genotoxicity of a technical grade organophosphate insecticide, Tafethion (ethion), in chicks.
Evaluation of genotoxicity of a technical grade organophosphate insecticide, Tafethion (ethion), in chicks.
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char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = b;code = 98
char = e;code = 101
char = r;code = 114
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = m;code = 109
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = The genotoxicity of a technical grade organophosphate insecticide, Tafethion (ethion), was evaluated in a chick in vivo test system employing the chromosome aberration assay (CA). Chicks in their neonatal life period are particularly susceptible to environmental contaminants due to the high rate of cell proliferation and ongoing process of development. This provides a new methodology to screen the genotoxic effect of environmental pollutants. The chemical was tested for three different doses (20, 15 and 10 mg/kg b.w.), in two routes of administration (i.p. and p.o.), after three different durations of acute exposure (6, 24 and 48 h) as well as chronic exposure (4 mg/kg day for 5 days), for the induction of chromosomal aberrations. Mitomycin C was used as the positive control. In general, the chemical induced higher frequencies of chromosomal aberrations than the controls, indicating the genotoxic property of the chemical in the tested system.

Publication: In Vivo 1994 Nov-Dec ;8(6)::1087-9.
Publication Date: 1994 Nov-Dec
Study Author(s): Bhunya, S P;Jena, G B;
Institution: Department of Zoology, Utkal University, Vani Vihar, Orissa, India.
Shortcut link to this study:
The genotoxicity of a technical grade organophosphate insecticide, Tafethion (ethion), was evaluated in a chick in vivo test system employing the chromosome aberration assay (CA). Chicks in their neonatal life period are particularly susceptible to environmental contaminants due to the high rate of cell proliferation and ongoing process of development. This provides a new methodology to screen the genotoxic effect of environmental pollutants. The chemical was tested for three different doses (20, 15 and 10 mg/kg b.w.), in two routes of administration (i.p. and p.o.), after three different durations of acute exposure (6, 24 and 48 h) as well as chronic exposure (4 mg/kg day for 5 days), for the induction of chromosomal aberrations. Mitomycin C was used as the positive control. In general, the chemical induced higher frequencies of chromosomal aberrations than the controls, indicating the genotoxic property of the chemical in the tested system.
PMID: 7772742

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