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To date, however, there are no published data concerning the efficacy of topical metronidazole in the treatment of acne. This randomized, double-blind prospective clinical study of 96 patients was performed to investigate the efficacy and tolerability of 0.75% metronidazole gel vs. placebo in the treatment of mild to moderate acne. The results of this study showed no significant benefit in using 0.75% metronidazole gel over placebo in reducing counts of inflamed and non-inflamed lesions of acne. There was also no statistically significant difference between the two groups at any stage in the trial when skin tolerability was assessed.
Publication: Clin. Exp. Dermatol. 1994 May ;19(3)::221-3.
Publication Date: 1994 May
Study Author(s): Tong, D;Peters, W;Barnetson, R S;
Institution: Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Shortcut link to this study:
Metronidazole, an imidazole, is an antibiotic with established efficacy against anaerobic bacteria. To date, however, there are no published data concerning the efficacy of topical metronidazole in the treatment of acne. This randomized, double-blind prospective clinical study of 96 patients was performed to investigate the efficacy and tolerability of 0.75% metronidazole gel vs. placebo in the treatment of mild to moderate acne. The results of this study showed no significant benefit in using 0.75% metronidazole gel over placebo in reducing counts of inflamed and non-inflamed lesions of acne. There was also no statistically significant difference between the two groups at any stage in the trial when skin tolerability was assessed.
PMID: 8033381