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result sql = The aging of the population has focused attention on the special needs of elderly patients. The increasing number of elderly people in the world's population has led to a parallel increase in the number of older cancer patients. Bias against older patients for screening and treatment of cancer exists, whereby effective therapies are withheld in the mistaken belief that these patients cannot tolerate them. Physiological changes which occur with aging include decreased cardiovascular performance, decreased haematopoietic tissue, a respiratory system which has been affected by life-long exposure to infection and toxins, decreasing renal function and a compromised nervous system. These changes have implications for drug toxicity such as possible increased sensitivity to cardiotoxins and increased haematological toxicity from myelosuppressive therapy. With the physiological decline in renal function with age, drug dosages must be carefully evaluated to avoid chemotherapy toxicity and its sequelae. Older patients may have increased sensitivity to oral toxicity, in particular, mucositis. There are also issues regarding tolerance of the older patient to radiation therapy. The haematopoietic growth factors and new antiemetics now available will allow chemotherapy to be administered with greater safety while maintaining quality of life. Overall, the healthy elderly are appropriate candidates for standard and experimental antineoplastic therapy. Careful assessment of end-organ function needs to be performed before a decision regarding the proper treatment regimen can be made. Clinical trials have rarely included the elderly, making data scarce. More research is needed in this age group.
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result sql = Physiological aspects of aging. Implications for the treatment of cancer.
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char = o;code = 111
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char = ;code = 32
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char = i;code = 105
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char = s;code = 115
char = o;code = 111
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char = e;code = 101
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char = i;code = 105
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char = p;code = 112
char = o;code = 111
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char = t;code = 116
char = i;code = 105
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char = m;code = 109
char = e;code = 101
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char = i;code = 105
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char = ;code = 32
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char = e;code = 101
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char = ;code = 32
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char = l;code = 108
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char = r;code = 114
char = e;code = 101
char = ;code = 32
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char = p;code = 112
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char = ;code = 32
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char = i;code = 105
char = d;code = 100
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char = e;code = 101
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
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char = a;code = 97
char = n;code = 110
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = o;code = 111
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = f;code = 102
char = u;code = 117
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = -;code = 45
char = o;code = 111
char = r;code = 114
char = g;code = 103
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = f;code = 102
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = e;code = 101
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = a;code = 97
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = d;code = 100
char = e;code = 101
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char = ;code = 32
char = C;code = 67
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = d;code = 100
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = l;code = 108
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = l;code = 108
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = ;code = 32
char = s;code = 115
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = e;code = 101
char = d;code = 100
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = The aging of the population has focused attention on the special needs of elderly patients. The increasing number of elderly people in the world's population has led to a parallel increase in the number of older cancer patients. Bias against older patients for screening and treatment of cancer exists, whereby effective therapies are withheld in the mistaken belief that these patients cannot tolerate them. Physiological changes which occur with aging include decreased cardiovascular performance, decreased haematopoietic tissue, a respiratory system which has been affected by life-long exposure to infection and toxins, decreasing renal function and a compromised nervous system. These changes have implications for drug toxicity such as possible increased sensitivity to cardiotoxins and increased haematological toxicity from myelosuppressive therapy. With the physiological decline in renal function with age, drug dosages must be carefully evaluated to avoid chemotherapy toxicity and its sequelae. Older patients may have increased sensitivity to oral toxicity, in particular, mucositis. There are also issues regarding tolerance of the older patient to radiation therapy. The haematopoietic growth factors and new antiemetics now available will allow chemotherapy to be administered with greater safety while maintaining quality of life. Overall, the healthy elderly are appropriate candidates for standard and experimental antineoplastic therapy. Careful assessment of end-organ function needs to be performed before a decision regarding the proper treatment regimen can be made. Clinical trials have rarely included the elderly, making data scarce. More research is needed in this age group.
Publication: Drugs Aging 1995 Sep ;7(3)::212-25.
Publication Date: 1995 Sep
Study Author(s): Lichtman, S M;
Institution: Don Monti Division of Medical Oncology, Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset, New York, USA.
Shortcut link to this study:
Publication Date: 1995 Sep
Study Author(s): Lichtman, S M;
Institution: Don Monti Division of Medical Oncology, Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset, New York, USA.
Shortcut link to this study:
The aging of the population has focused attention on the special needs of elderly patients. The increasing number of elderly people in the world's population has led to a parallel increase in the number of older cancer patients. Bias against older patients for screening and treatment of cancer exists, whereby effective therapies are withheld in the mistaken belief that these patients cannot tolerate them. Physiological changes which occur with aging include decreased cardiovascular performance, decreased haematopoietic tissue, a respiratory system which has been affected by life-long exposure to infection and toxins, decreasing renal function and a compromised nervous system. These changes have implications for drug toxicity such as possible increased sensitivity to cardiotoxins and increased haematological toxicity from myelosuppressive therapy. With the physiological decline in renal function with age, drug dosages must be carefully evaluated to avoid chemotherapy toxicity and its sequelae. Older patients may have increased sensitivity to oral toxicity, in particular, mucositis. There are also issues regarding tolerance of the older patient to radiation therapy. The haematopoietic growth factors and new antiemetics now available will allow chemotherapy to be administered with greater safety while maintaining quality of life. Overall, the healthy elderly are appropriate candidates for standard and experimental antineoplastic therapy. Careful assessment of end-organ function needs to be performed before a decision regarding the proper treatment regimen can be made. Clinical trials have rarely included the elderly, making data scarce. More research is needed in this age group.
PMID: 8535051
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Related Concepts
How is this determined?
The order of these related concepts is determined by a statistical analysis of the scientific literature. Highest-frequency concepts appear first.
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