|
|
char = E;code = 69
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = R;code = 82
char = O;code = 79
char = S;code = 83
char = );code = 41
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = T;code = 84
char = E;code = 69
char = M;code = 77
char = P;code = 80
char = O;code = 79
char = L;code = 76
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = d;code = 100
char = e;code = 101
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = M;code = 77
char = A;code = 65
char = L;code = 76
char = D;code = 68
char = );code = 41
char = ;code = 32
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = b;code = 98
char = e;code = 101
char = r;code = 114
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = C;code = 67
char = h;code = 104
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = m;code = 109
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = v;code = 118
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = (;code = 40
char = C;code = 67
char = H;code = 72
char = O;code = 79
char = );code = 41
char = -;code = 45
char = A;code = 65
char = S;code = 83
char = 5;code = 53
char = 2;code = 50
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Effects of reactive oxygen species (ROS) modulators, TEMPOL and catalase, on methoxyacetaldehyde (MALD) -induced chromosome aberrations in Chinese hamster ovary (CHO)-AS52 cells.
Effects of reactive oxygen species (ROS) modulators, TEMPOL and catalase, on methoxyacetaldehyde (MALD) -induced chromosome aberrations in Chinese hamster ovary (CHO)-AS52 cells.char = M;code = 77
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = d;code = 100
char = e;code = 101
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = M;code = 77
char = A;code = 65
char = L;code = 76
char = D;code = 68
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 2;code = 50
char = -;code = 45
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = C;code = 67
char = H;code = 72
char = O;code = 79
char = -;code = 45
char = A;code = 65
char = S;code = 83
char = 5;code = 53
char = 2;code = 50
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = P;code = 80
char = C;code = 67
char = R;code = 82
char = -;code = 45
char = b;code = 98
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = -;code = 45
char = d;code = 100
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = M;code = 77
char = A;code = 65
char = L;code = 76
char = D;code = 68
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = C;code = 67
char = H;code = 72
char = O;code = 79
char = -;code = 45
char = A;code = 65
char = S;code = 83
char = 5;code = 53
char = 2;code = 50
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = M;code = 77
char = A;code = 65
char = L;code = 76
char = D;code = 68
char = ;code = 32
char = i;code = 105
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char = d;code = 100
char = u;code = 117
char = c;code = 99
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char = s;code = 115
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = S;code = 83
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = M;code = 77
char = A;code = 65
char = L;code = 76
char = D;code = 68
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = d;code = 100
char = e;code = 101
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = d;code = 100
char = e;code = 101
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ,;code = 44
char = ;code = 32
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char = d;code = 100
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char = g;code = 103
char = e;code = 101
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char = ;code = 32
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char = e;code = 101
char = r;code = 114
char = o;code = 111
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char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = l;code = 108
char = ;code = 32
char = r;code = 114
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char = i;code = 105
char = c;code = 99
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char = );code = 41
char = ;code = 32
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char = b;code = 98
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = x;code = 120
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char = M;code = 77
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char = .;code = 46
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char = T;code = 84
char = E;code = 69
char = M;code = 77
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char = O;code = 79
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char = R;code = 82
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char = d;code = 100
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char = a;code = 97
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char = o;code = 111
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char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = u;code = 117
char = s;code = 115
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char = o;code = 111
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char = t;code = 116
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char = d;code = 100
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char = ;code = 32
char = t;code = 116
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char = f;code = 102
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char = c;code = 99
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char = l;code = 108
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char = T;code = 84
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char = T;code = 84
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char = O;code = 79
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char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = c;code = 99
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char = c;code = 99
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result sql = Methoxyacetaldehyde (MALD), a metabolite of 2-methoxyethanol, has been shown to be clastogenic and mutagenic in CHO-AS52 cells. PCR-based-deletion screening of MALD induced CHO-AS52 mutants indicates that MALD induces large deletion mutation. Since MALD has an aldehyde as its reactive functional group, it can react with aldehyde oxidase to produce superoxide. The generation of these reactive oxygen species (superoxide, hydrogen peroxide and hydroxyl radical) may be the mechanism for genotoxicity of MALD. In the present study, TEMPOL and catalase which are ROS modulators were used to study the effects on MALD-induced chromosome damage in CHO-AS52 cells. The results showed that neither TEMPOL nor catalase can protect cells from MALD-induced chromosome aberrations. Therefore, the generation of reactive oxygen species may not be the primary mechanism of action of MALD.
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char = ;code = 32
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char = v;code = 118
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char = c;code = 99
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char = .;code = 46
result sql = Effects of reactive oxygen species (ROS) modulators, TEMPOL and catalase, on methoxyacetaldehyde (MALD) -induced chromosome aberrations in Chinese hamster ovary (CHO)-AS52 cells.
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result sql = Methoxyacetaldehyde (MALD), a metabolite of 2-methoxyethanol, has been shown to be clastogenic and mutagenic in CHO-AS52 cells. PCR-based-deletion screening of MALD induced CHO-AS52 mutants indicates that MALD induces large deletion mutation. Since MALD has an aldehyde as its reactive functional group, it can react with aldehyde oxidase to produce superoxide. The generation of these reactive oxygen species (superoxide, hydrogen peroxide and hydroxyl radical) may be the mechanism for genotoxicity of MALD. In the present study, TEMPOL and catalase which are ROS modulators were used to study the effects on MALD-induced chromosome damage in CHO-AS52 cells. The results showed that neither TEMPOL nor catalase can protect cells from MALD-induced chromosome aberrations. Therefore, the generation of reactive oxygen species may not be the primary mechanism of action of MALD.
Publication: Mutat. Res. 1996 Oct 25 ;357(1-2)::25-33.
Publication Date: 1996 Oct 25
Study Author(s): Ratanavalachai, T C;Au, W W;
Institution: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand. mdbci010.chiangmai.ac.th
Shortcut link to this study:
Publication Date: 1996 Oct 25
Study Author(s): Ratanavalachai, T C;Au, W W;
Institution: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand. mdbci010.chiangmai.ac.th
Shortcut link to this study:
Methoxyacetaldehyde (MALD), a metabolite of 2-methoxyethanol, has been shown to be clastogenic and mutagenic in CHO-AS52 cells. PCR-based-deletion screening of MALD induced CHO-AS52 mutants indicates that MALD induces large deletion mutation. Since MALD has an aldehyde as its reactive functional group, it can react with aldehyde oxidase to produce superoxide. The generation of these reactive oxygen species (superoxide, hydrogen peroxide and hydroxyl radical) may be the mechanism for genotoxicity of MALD. In the present study, TEMPOL and catalase which are ROS modulators were used to study the effects on MALD-induced chromosome damage in CHO-AS52 cells. The results showed that neither TEMPOL nor catalase can protect cells from MALD-induced chromosome aberrations. Therefore, the generation of reactive oxygen species may not be the primary mechanism of action of MALD.
PMID: 8876677
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