|
|
char = I;code = 73
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
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char = i;code = 105
char = n;code = 110
char = ;code = 32
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char = a;code = 97
char = m;code = 109
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = f;code = 102
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
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char = k;code = 107
char = e;code = 101
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
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char = m;code = 109
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char = n;code = 110
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char = i;code = 105
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char = i;code = 105
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char = t;code = 116
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.
Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
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char = m;code = 109
char = o;code = 111
char = n;code = 110
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char = o;code = 111
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char = n;code = 110
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char = i;code = 105
char = s;code = 115
char = ;code = 32
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char = u;code = 117
char = r;code = 114
char = o;code = 111
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char = r;code = 114
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char = t;code = 116
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char = v;code = 118
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char = i;code = 105
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char = n;code = 110
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char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
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char = i;code = 105
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = n;code = 110
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char = e;code = 101
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = i;code = 105
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char = d;code = 100
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char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
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char = i;code = 105
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char = ,;code = 44
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = c;code = 99
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char = r;code = 114
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
char = m;code = 109
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char = l;code = 108
char = l;code = 108
char = y;code = 121
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char = d;code = 100
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char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ,;code = 44
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char = h;code = 104
char = e;code = 101
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char = b;code = 98
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char = a;code = 97
char = i;code = 105
char = n;code = 110
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char = m;code = 109
char = i;code = 105
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char = t;code = 116
char = ;code = 32
char = b;code = 98
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char = i;code = 105
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
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char = r;code = 114
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char = s;code = 115
char = k;code = 107
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = n;code = 110
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char = r;code = 114
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char = e;code = 101
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char = a;code = 97
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char = .;code = 46
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char = H;code = 72
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char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = n;code = 110
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char = n;code = 110
char = ;code = 32
char = d;code = 100
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char = f;code = 102
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char = c;code = 99
char = i;code = 105
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char = c;code = 99
char = y;code = 121
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char = d;code = 100
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = u;code = 117
char = l;code = 108
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = c;code = 99
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = m;code = 109
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char = a;code = 97
char = t;code = 116
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char = i;code = 105
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char = c;code = 99
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char = s;code = 115
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char = y;code = 121
char = ;code = 32
char = p;code = 112
char = i;code = 105
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char = e;code = 101
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = n;code = 110
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char = ;code = 32
char = f;code = 102
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char = c;code = 99
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char = l;code = 108
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char = b;code = 98
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char = i;code = 105
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char = .;code = 46
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char = O;code = 79
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char = r;code = 114
char = e;code = 101
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char = s;code = 115
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char = g;code = 103
char = g;code = 103
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result sql = The pineal hormone melatonin is neuroprotective in vitro, and in vivo it is neuroprotective when given in pharmacological doses. Consequently, it has been hypothesized that with aging, as circulating levels of melatonin in mammals normally decrease, the brain might be at increased risk of neurodegeneration. However, direct evidence that melatonin deficiency leads to increased brain vulnerability is still lacking. We created melatonin deficiency in rats by pinealectomy and induced neurodegeneration by two models of focal brain ischemia/stroke and by glutamate receptor-mediated, epilepsy-like seizures. We observed greater neurodegeneration in melatonin-deficient animals than in controls. Our results suggest that endogenous melatonin may play a neuroprotective role, and that melatonin deficiency might be a pathophysiological mechanism in neurodegenerative diseases.
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char = t;code = 116
char = s;code = 115
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result sql = Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.
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result sql = The pineal hormone melatonin is neuroprotective in vitro, and in vivo it is neuroprotective when given in pharmacological doses. Consequently, it has been hypothesized that with aging, as circulating levels of melatonin in mammals normally decrease, the brain might be at increased risk of neurodegeneration. However, direct evidence that melatonin deficiency leads to increased brain vulnerability is still lacking. We created melatonin deficiency in rats by pinealectomy and induced neurodegeneration by two models of focal brain ischemia/stroke and by glutamate receptor-mediated, epilepsy-like seizures. We observed greater neurodegeneration in melatonin-deficient animals than in controls. Our results suggest that endogenous melatonin may play a neuroprotective role, and that melatonin deficiency might be a pathophysiological mechanism in neurodegenerative diseases.
Publication: FASEB J. 1996 Nov ;10(13)::1546-51.
Publication Date: 1996 Nov
Study Author(s): Manev, H;Uz, T;Kharlamov, A;Joo, J Y;
Institution: The Psychiatric Institute, University of Illinois, Chicago 60612, USA.
Shortcut link to this study:
Publication Date: 1996 Nov
Study Author(s): Manev, H;Uz, T;Kharlamov, A;Joo, J Y;
Institution: The Psychiatric Institute, University of Illinois, Chicago 60612, USA.
Shortcut link to this study:
The pineal hormone melatonin is neuroprotective in vitro, and in vivo it is neuroprotective when given in pharmacological doses. Consequently, it has been hypothesized that with aging, as circulating levels of melatonin in mammals normally decrease, the brain might be at increased risk of neurodegeneration. However, direct evidence that melatonin deficiency leads to increased brain vulnerability is still lacking. We created melatonin deficiency in rats by pinealectomy and induced neurodegeneration by two models of focal brain ischemia/stroke and by glutamate receptor-mediated, epilepsy-like seizures. We observed greater neurodegeneration in melatonin-deficient animals than in controls. Our results suggest that endogenous melatonin may play a neuroprotective role, and that melatonin deficiency might be a pathophysiological mechanism in neurodegenerative diseases.
PMID: 8940301
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