|
|
char = P;code = 80
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char = i;code = 105
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char = s;code = 115
char = o;code = 111
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result sql = Possible involvement of nitric oxide in the sensorineural hearing loss of bacterial meningitis.
Possible involvement of nitric oxide in the sensorineural hearing loss of bacterial meningitis.char = M;code = 77
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char = n;code = 110
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char = o;code = 111
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char = ;code = 32
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char = h;code = 104
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char = t;code = 116
char = h;code = 104
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char = N;code = 78
char = O;code = 79
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char = d;code = 100
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char = ,;code = 44
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char = s;code = 115
char = i;code = 105
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char = ;code = 32
char = (;code = 40
char = S;code = 83
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char = P;code = 80
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char = l;code = 108
char = a;code = 97
char = m;code = 109
char = i;code = 105
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char = ;code = 32
char = (;code = 40
char = S;code = 83
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char = ,;code = 44
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char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = r;code = 114
char = k;code = 107
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = o;code = 111
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char = p;code = 112
char = o;code = 111
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char = a;code = 97
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char = (;code = 40
char = C;code = 67
char = A;code = 65
char = P;code = 80
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = c;code = 99
char = o;code = 111
char = c;code = 99
char = h;code = 104
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
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char = o;code = 111
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char = c;code = 99
char = ;code = 32
char = (;code = 40
char = C;code = 67
char = M;code = 77
char = );code = 41
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = e;code = 101
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = w;code = 119
char = i;code = 105
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char = h;code = 104
char = ;code = 32
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char = v;code = 118
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char = h;code = 104
char = a;code = 97
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char = ;code = 32
char = c;code = 99
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char = l;code = 108
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char = s;code = 115
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char = l;code = 108
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char = i;code = 105
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = g;code = 103
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = .;code = 46
char = ;code = 32
char = I;code = 73
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char = ;code = 32
char = a;code = 97
char = d;code = 100
char = d;code = 100
char = i;code = 105
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char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = d;code = 100
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char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = N;code = 78
char = -;code = 45
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
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char = D;code = 68
char = -;code = 45
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char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = N;code = 78
char = M;code = 77
char = D;code = 68
char = A;code = 65
char = );code = 41
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = s;code = 115
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = a;code = 97
char = ;code = 32
char = t;code = 116
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
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char = b;code = 98
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char = b;code = 98
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char = N;code = 78
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char = A;code = 65
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result sql = Microperfusion of scala tympani with the NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP), produced marked depression of the compound action potential (CAP) and cochlear microphonic (CM) together with severe and widespread morphological damage to hair cells and supporting cells in the organ of Corti. In addition, direct perfusion of N-methyl-D-aspartate (NMDA) into scala tympani, which probably induces excess stimulation of NMDA receptors within the cochlea and which is known to lead to the release of NO, was found to elicit similar electrophysiological and structural lesions in the cochlea. Pre-perfusion of scala tympani with L-methyl arginine (L-MA), which inhibits the release of NO, or superoxide dismutase (SOD), an O2-scavenger, conferred marked protection upon the cochlea from the lesions caused by NO donors. These observations indicate that enhanced NO production is likely to be an important factor responsible for pathological insult of the cochlea. The possibility is discussed that this factor is involved in the chain of events leading to hearing loss caused by bacterial meningitis. Such hearing loss is a major sequela of bacterial meningitis in children.
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result sql = Possible involvement of nitric oxide in the sensorineural hearing loss of bacterial meningitis.
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result sql = Microperfusion of scala tympani with the NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP), produced marked depression of the compound action potential (CAP) and cochlear microphonic (CM) together with severe and widespread morphological damage to hair cells and supporting cells in the organ of Corti. In addition, direct perfusion of N-methyl-D-aspartate (NMDA) into scala tympani, which probably induces excess stimulation of NMDA receptors within the cochlea and which is known to lead to the release of NO, was found to elicit similar electrophysiological and structural lesions in the cochlea. Pre-perfusion of scala tympani with L-methyl arginine (L-MA), which inhibits the release of NO, or superoxide dismutase (SOD), an O2-scavenger, conferred marked protection upon the cochlea from the lesions caused by NO donors. These observations indicate that enhanced NO production is likely to be an important factor responsible for pathological insult of the cochlea. The possibility is discussed that this factor is involved in the chain of events leading to hearing loss caused by bacterial meningitis. Such hearing loss is a major sequela of bacterial meningitis in children.
Publication: Acta Otolaryngol. 1997 May ;117(3)::329-36.
Publication Date: 1997 May
Study Author(s): Amaee, F R;Comis, S D;Osborne, M P;Drew, S;Tarlow, M J;
Institution: Department of Physiology, Medical School, University of Birmingham, UK.
Shortcut link to this study:
Publication Date: 1997 May
Study Author(s): Amaee, F R;Comis, S D;Osborne, M P;Drew, S;Tarlow, M J;
Institution: Department of Physiology, Medical School, University of Birmingham, UK.
Shortcut link to this study:
Microperfusion of scala tympani with the NO donors, sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine (SNAP), produced marked depression of the compound action potential (CAP) and cochlear microphonic (CM) together with severe and widespread morphological damage to hair cells and supporting cells in the organ of Corti. In addition, direct perfusion of N-methyl-D-aspartate (NMDA) into scala tympani, which probably induces excess stimulation of NMDA receptors within the cochlea and which is known to lead to the release of NO, was found to elicit similar electrophysiological and structural lesions in the cochlea. Pre-perfusion of scala tympani with L-methyl arginine (L-MA), which inhibits the release of NO, or superoxide dismutase (SOD), an O2-scavenger, conferred marked protection upon the cochlea from the lesions caused by NO donors. These observations indicate that enhanced NO production is likely to be an important factor responsible for pathological insult of the cochlea. The possibility is discussed that this factor is involved in the chain of events leading to hearing loss caused by bacterial meningitis. Such hearing loss is a major sequela of bacterial meningitis in children.
PMID: 9199517
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