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result sql = The pH dependence of silicon-iron interaction in rats.
The pH dependence of silicon-iron interaction in rats.
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char = a;code = 97
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char = 1;code = 49
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char = %;code = 37
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char = f;code = 102
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char = t;code = 116
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char = r;code = 114
char = o;code = 111
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char = );code = 41
char = .;code = 46
char = ;code = 32
char = T;code = 84
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char = e;code = 101
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char = s;code = 115
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char = p;code = 112
char = p;code = 112
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char = e;code = 101
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char = n;code = 110
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char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = n;code = 110
char = ;code = 32
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char = f;code = 102
char = ;code = 32
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char = 0;code = 48
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char = c;code = 99
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char = u;code = 117
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result sql = A 2 x 2 x 3 factorial experiment was conducted to study the pH dependence of a silicon-iron interaction in vivo. The dietary treatments used in the factorial design were the following (mg/kg of diet): silicon, 0 and 500; iron, 35 and 187; acid-base, ammonium chloride as 0.5% of total diet (acidic), sodium bicarbonate as 1.0% of total diet (basic), or no supplementation of acid or base (control). The supplementation of 500 mg silicon/kg of diet increased plasma-iron concentration in rats fed the acidic or control diets, but not in rats fed the basic diet. A high dietary-iron level suppressed copper absorption and utilization and subsequently imposed a negative effect on its own utilization. An increase in the plasma total-cholesterol concentration caused by high dietary-iron level was likely a consequence of the antagonistic effect of iron on copper absorption and utilization. The use of cupric sulfate pentahydrate as the dietary-copper source in this study resulted in plasma copper concentrations that were approximately twice those obtained in a related study using cupric carbonate. Also, a 42% coefficient of variation (C.V.) for plasma-copper concentrations of rats fed cupric sulfate in this study was greatly reduced from the C.V. = 108% previously associated with the dietary cupric carbonate.

Publication: Biol Trace Elem Res 1997 Winter ;59(1-3)::113-22.
Publication Date: 1997 Winter
Study Author(s): Jia, X;Emerick, R J;Kayongo-Male, H;
Institution: Department of Chemistry and Biochemistry, South Dakota State University, Brookings 57007, USA.
Shortcut link to this study:
A 2 x 2 x 3 factorial experiment was conducted to study the pH dependence of a silicon-iron interaction in vivo. The dietary treatments used in the factorial design were the following (mg/kg of diet): silicon, 0 and 500; iron, 35 and 187; acid-base, ammonium chloride as 0.5% of total diet (acidic), sodium bicarbonate as 1.0% of total diet (basic), or no supplementation of acid or base (control). The supplementation of 500 mg silicon/kg of diet increased plasma-iron concentration in rats fed the acidic or control diets, but not in rats fed the basic diet. A high dietary-iron level suppressed copper absorption and utilization and subsequently imposed a negative effect on its own utilization. An increase in the plasma total-cholesterol concentration caused by high dietary-iron level was likely a consequence of the antagonistic effect of iron on copper absorption and utilization. The use of cupric sulfate pentahydrate as the dietary-copper source in this study resulted in plasma copper concentrations that were approximately twice those obtained in a related study using cupric carbonate. Also, a 42% coefficient of variation (C.V.) for plasma-copper concentrations of rats fed cupric sulfate in this study was greatly reduced from the C.V. = 108% previously associated with the dietary cupric carbonate.
PMID: 9522053

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