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char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = e;code = 101
char = n;code = 110
char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = c;code = 99
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char = b;code = 98
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char = k;code = 107
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char = d;code = 100
char = e;code = 101
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char = d;code = 100
char = o;code = 111
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = c;code = 99
char = y;code = 121
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char = h;code = 104
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = v;code = 118
char = o;code = 111
char = l;code = 108
char = u;code = 117
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = 4;code = 52
char = 3;code = 51
char = 0;code = 48
char = 0;code = 48
char = ;code = 32
char = m;code = 109
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = e;code = 101
char = .;code = 46
result sql = Beta-adrenergic blockade does not prevent polycythemia or decrease in plasma volume in men at 4300 m altitude.
Beta-adrenergic blockade does not prevent polycythemia or decrease in plasma volume in men at 4300 m altitude.
char = W;code = 87
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char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = o;code = 111
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char = h;code = 104
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char = g;code = 103
char = h;code = 104
char = ;code = 32
char = a;code = 97
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char = t;code = 116
char = u;code = 117
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char = e;code = 101
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char = (;code = 40
char = A;code = 65
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char = T;code = 84
char = );code = 41
char = ;code = 32
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char = e;code = 101
char = i;code = 105
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char = p;code = 112
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = m;code = 109
char = a;code = 97
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char = v;code = 118
char = o;code = 111
char = l;code = 108
char = u;code = 117
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char = e;code = 101
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char = (;code = 40
char = P;code = 80
char = V;code = 86
char = );code = 41
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char = t;code = 116
char = a;code = 97
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char = b;code = 98
char = l;code = 108
char = o;code = 111
char = o;code = 111
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char = o;code = 111
char = l;code = 108
char = u;code = 117
char = m;code = 109
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char = ;code = 32
char = (;code = 40
char = B;code = 66
char = V;code = 86
char = );code = 41
char = ;code = 32
char = d;code = 100
char = e;code = 101
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = r;code = 114
char = s;code = 115
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char = ;code = 32
char = f;code = 102
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char = w;code = 119
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = y;code = 121
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = W;code = 87
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = u;code = 117
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = ;code = 32
char = o;code = 111
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char = e;code = 101
char = r;code = 114
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = v;code = 118
char = e;code = 101
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char = a;code = 97
char = l;code = 108
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char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
char = ,;code = 44
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char = e;code = 101
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char = h;code = 104
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char = a;code = 97
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char = i;code = 105
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char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = m;code = 109
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
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char = y;code = 121
char = t;code = 116
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char = r;code = 114
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char = p;code = 112
char = o;code = 111
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char = i;code = 105
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char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = r;code = 114
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char = d;code = 100
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char = c;code = 99
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char = c;code = 99
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char = t;code = 116
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char = r;code = 114
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = o;code = 111
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char = e;code = 101
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char = B;code = 66
char = V;code = 86
char = .;code = 46
char = ;code = 32
char = B;code = 66
char = e;code = 101
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char = a;code = 97
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char = s;code = 115
char = e;code = 101
char = ;code = 32
char = h;code = 104
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char = p;code = 112
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char = a;code = 97
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = e;code = 101
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char = a;code = 97
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char = a;code = 97
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char = r;code = 114
char = e;code = 101
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char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = c;code = 99
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char = s;code = 115
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char = s;code = 115
char = t;code = 116
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char = c;code = 99
char = h;code = 104
char = ;code = 32
char = s;code = 115
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char = m;code = 109
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char = l;code = 108
char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = r;code = 114
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char = o;code = 111
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char = c;code = 99
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char = l;code = 108
char = ;code = 32
char = p;code = 112
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char = d;code = 100
char = u;code = 117
char = c;code = 99
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char = i;code = 105
char = o;code = 111
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char = ,;code = 44
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char = w;code = 119
char = e;code = 101
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char = i;code = 105
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char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = g;code = 103
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = o;code = 111
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char = ;code = 32
char = a;code = 97
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char = e;code = 101
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char = e;code = 101
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char = f;code = 102
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char = 1;code = 49
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char = A;code = 65
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char = a;code = 97
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char = V;code = 86
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char = a;code = 97
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char = r;code = 114
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char = p;code = 112
char = o;code = 111
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char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = c;code = 99
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char = n;code = 110
char = c;code = 99
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = n;code = 110
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char = [;code = 91
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char = P;code = 80
char = O;code = 79
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char = );code = 41
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
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char = c;code = 99
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char = n;code = 110
char = t;code = 116
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char = r;code = 114
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char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = d;code = 100
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = n;code = 110
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char = d;code = 100
char = .;code = 46
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char = A;code = 65
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char = l;code = 108
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = a;code = 97
char = f;code = 102
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = 9;code = 57
char = -;code = 45
char = 1;code = 49
char = 1;code = 49
char = ;code = 32
char = (;code = 40
char = A;code = 65
char = L;code = 76
char = T;code = 84
char = -;code = 45
char = 1;code = 49
char = 0;code = 48
char = );code = 41
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = 1;code = 49
char = 9;code = 57
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char = 2;code = 50
char = 0;code = 48
char = ;code = 32
char = (;code = 40
char = A;code = 65
char = L;code = 76
char = T;code = 84
char = -;code = 45
char = 2;code = 50
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char = );code = 41
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = y;code = 121
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = A;code = 65
char = L;code = 76
char = T;code = 84
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = A;code = 65
char = L;code = 76
char = T;code = 84
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = x;code = 120
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = ,;code = 44
char = ;code = 32
char = 2;code = 50
char = 4;code = 52
char = 0;code = 48
char = ;code = 32
char = m;code = 109
char = g;code = 103
char = ;code = 32
char = x;code = 120
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = y;code = 121
char = [;code = 91
char = -;code = 45
char = 1;code = 49
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char = );code = 41
char = ,;code = 44
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = b;code = 98
char = o;code = 111
char = ;code = 32
char = (;code = 40
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = );code = 41
char = .;code = 46
char = ;code = 32
char = E;code = 69
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = -;code = 45
char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = k;code = 107
char = a;code = 97
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = m;code = 109
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char = d;code = 100
char = i;code = 105
char = f;code = 102
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = S;code = 83
char = E;code = 69
char = );code = 41
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = x;code = 120
char = i;code = 105
char = m;code = 109
char = a;code = 97
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char = ;code = 32
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = [;code = 91
char = E;code = 69
char = P;code = 80
char = O;code = 79
char = ];code = 93
char = ;code = 32
char = [;code = 91
char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = ;code = 32
char = 2;code = 50
char = 4;code = 52
char = .;code = 46
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char = (;code = 40
char = 3;code = 51
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char = 5;code = 53
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char = ;code = 32
char = v;code = 118
char = s;code = 115
char = ;code = 32
char = p;code = 112
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char = o;code = 111
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char = ;code = 32
char = 2;code = 50
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char = .;code = 46
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char = (;code = 40
char = 1;code = 49
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char = ;code = 32
char = m;code = 109
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char = ;code = 32
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char = ;code = 32
char = m;code = 109
char = l;code = 108
char = (;code = 40
char = -;code = 45
char = 1;code = 49
char = );code = 41
char = ];code = 93
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = u;code = 117
char = l;code = 108
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char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = n;code = 110
char = t;code = 116
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char = [;code = 91
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = :;code = 58
char = ;code = 32
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char = (;code = 40
char = 0;code = 48
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char = 7;code = 55
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char = ;code = 32
char = v;code = 118
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = ;code = 32
char = 2;code = 50
char = .;code = 46
char = 2;code = 50
char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 5;code = 53
char = );code = 41
char = %;code = 37
char = ];code = 93
char = ;;code = 59
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
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char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = P;code = 80
char = V;code = 86
char = E;code = 69
char = B;code = 66
char = ;code = 32
char = [;code = 91
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = :;code = 58
char = ;code = 32
char = -;code = 45
char = 1;code = 49
char = 5;code = 53
char = .;code = 46
char = 8;code = 56
char = ;code = 32
char = (;code = 40
char = 3;code = 51
char = .;code = 46
char = 8;code = 56
char = );code = 41
char = ;code = 32
char = v;code = 118
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = :;code = 58
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char = -;code = 45
char = 1;code = 49
char = 9;code = 57
char = .;code = 46
char = 9;code = 57
char = ;code = 32
char = (;code = 40
char = 2;code = 50
char = .;code = 46
char = 8;code = 56
char = );code = 41
char = %;code = 37
char = ];code = 93
char = ,;code = 44
char = ;code = 32
char = R;code = 82
char = C;code = 67
char = V;code = 86
char = C;code = 67
char = O;code = 79
char = ;code = 32
char = [;code = 91
char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = ;code = 32
char = +;code = 43
char = 7;code = 55
char = .;code = 46
char = 0;code = 48
char = ;code = 32
char = (;code = 40
char = 6;code = 54
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char = 7;code = 55
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char = ;code = 32
char = v;code = 118
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = :;code = 58
char = ;code = 32
char = +;code = 43
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = .;code = 46
char = 1;code = 49
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char = (;code = 40
char = 6;code = 54
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char = 1;code = 49
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char = %;code = 37
char = ];code = 93
char = ,;code = 44
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = B;code = 66
char = V;code = 86
char = C;code = 67
char = O;code = 79
char = ;code = 32
char = [;code = 91
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = :;code = 58
char = ;code = 32
char = -;code = 45
char = 7;code = 55
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char = 3;code = 51
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char = (;code = 40
char = 2;code = 50
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char = 3;code = 51
char = );code = 41
char = ;code = 32
char = v;code = 118
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = -;code = 45
char = 7;code = 55
char = .;code = 46
char = 1;code = 49
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char = (;code = 40
char = 3;code = 51
char = .;code = 46
char = 9;code = 57
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char = %;code = 37
char = ];code = 93
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = a;code = 97
char = b;code = 98
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char = c;code = 99
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char = f;code = 102
char = ;code = 32
char = w;code = 119
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char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
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char = s;code = 115
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = b;code = 98
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char = a;code = 97
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char = e;code = 101
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char = s;code = 115
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char = i;code = 105
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char = i;code = 105
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char = l;code = 108
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char = .;code = 46
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char = H;code = 72
char = e;code = 101
char = n;code = 110
char = c;code = 99
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char = ;code = 32
char = a;code = 97
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char = v;code = 118
char = a;code = 97
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char = o;code = 111
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char = o;code = 111
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char = t;code = 116
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char = e;code = 101
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char = b;code = 98
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char = a;code = 97
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char = r;code = 114
char = g;code = 103
char = i;code = 105
char = c;code = 99
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char = i;code = 105
char = d;code = 100
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char = a;code = 97
char = p;code = 112
char = p;code = 112
char = e;code = 101
char = a;code = 97
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char = t;code = 116
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char = a;code = 97
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char = f;code = 102
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = h;code = 104
char = y;code = 121
char = p;code = 112
char = o;code = 111
char = v;code = 118
char = o;code = 111
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char = e;code = 101
char = m;code = 109
char = i;code = 105
char = c;code = 99
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char = o;code = 111
char = r;code = 114
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char = p;code = 112
char = o;code = 111
char = l;code = 108
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char = y;code = 121
char = t;code = 116
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = ;code = 32
char = o;code = 111
char = c;code = 99
char = c;code = 99
char = u;code = 117
char = r;code = 114
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char = e;code = 101
char = d;code = 100
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char = d;code = 100
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = 3;code = 51
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char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = 4;code = 52
char = 3;code = 51
char = 0;code = 48
char = 0;code = 48
char = ;code = 32
char = m;code = 109
char = ;code = 32
char = A;code = 65
char = L;code = 76
char = T;code = 84
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
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result sql = When humans ascend to high altitude (ALT) their plasma volume (PV) and total blood volume (BV) decrease during the first few days. With continued residence over several weeks, the hypoxia-induced stimulation of erythropoietin increases red cell production which tends to restore BV. Because hypoxia also activates the beta-adrenergic system, which stimulates red blood cell production, we investigated the effect of adrenergic beta-receptor inhibition with propranolol on fluid volumes and the polycythemic response in 11 healthy unacclimatized men (21-33 years old exposed to an ALT of 4300 m (barometric pressure 460 Torr) for 3 weeks on Pikes Peak, Colorado. PV was determined by the Evans blue dye method (PVEB), BV by the carbon monoxide method (BVCO), red cell volume (RCV) was calculated from hematocrit (Hct) and BVCO, and serum erythropoietin concentration ([EPO]) and reticulocyte count, were also determined. All determinations were made at sea level and after 9-11 (ALT-10) and 19-20 (ALT-20) days at ALT. At sea level and ALT, six men received propranolol (pro, 240 mg x day[-1]), and five received a placebo (pla). Effective beta-blockade did not modify the mean (SE) maximal values of [EPO] [pla: 24.9 (3.5) vs pro: 24.5 (1.5) mU x ml(-1)] or reticulocyte count [pla: 2.7 (0.7) vs pro: 2.2 (0.5)%]; nor changes in PVEB [pla: -15.8 (3.8) vs pro: -19.9 (2.8)%], RCVCO [pla: +7.0 (6.7) vs pro: + 10.1 (6.1)%], or BVCO [pla: -7.3 (2.3) vs pro: -7.1 (3.9)%]. In the absence of weight loss, a redistribution of body water with no net loss is implied. Hence, activation of the beta-adrenergic system did not appear to affect the hypovolemic or polycythemic responses that occurred during 3 weeks at 4300 m ALT in these subjects.

Publication: Eur J Appl Physiol Occup Physiol 1998 Feb ;77(3)::264-70.
Publication Date: 1998 Feb
Study Author(s): Grover, R F;Selland, M A;McCullough, R G;Dahms, T E;Wolfel, E E;Butterfield, G E;Reeves, J T;Greenleaf, J E;
Institution: Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262, USA.
Shortcut link to this study:
When humans ascend to high altitude (ALT) their plasma volume (PV) and total blood volume (BV) decrease during the first few days. With continued residence over several weeks, the hypoxia-induced stimulation of erythropoietin increases red cell production which tends to restore BV. Because hypoxia also activates the beta-adrenergic system, which stimulates red blood cell production, we investigated the effect of adrenergic beta-receptor inhibition with propranolol on fluid volumes and the polycythemic response in 11 healthy unacclimatized men (21-33 years old exposed to an ALT of 4300 m (barometric pressure 460 Torr) for 3 weeks on Pikes Peak, Colorado. PV was determined by the Evans blue dye method (PVEB), BV by the carbon monoxide method (BVCO), red cell volume (RCV) was calculated from hematocrit (Hct) and BVCO, and serum erythropoietin concentration ([EPO]) and reticulocyte count, were also determined. All determinations were made at sea level and after 9-11 (ALT-10) and 19-20 (ALT-20) days at ALT. At sea level and ALT, six men received propranolol (pro, 240 mg x day[-1]), and five received a placebo (pla). Effective beta-blockade did not modify the mean (SE) maximal values of [EPO] [pla: 24.9 (3.5) vs pro: 24.5 (1.5) mU x ml(-1)] or reticulocyte count [pla: 2.7 (0.7) vs pro: 2.2 (0.5)%]; nor changes in PVEB [pla: -15.8 (3.8) vs pro: -19.9 (2.8)%], RCVCO [pla: +7.0 (6.7) vs pro: + 10.1 (6.1)%], or BVCO [pla: -7.3 (2.3) vs pro: -7.1 (3.9)%]. In the absence of weight loss, a redistribution of body water with no net loss is implied. Hence, activation of the beta-adrenergic system did not appear to affect the hypovolemic or polycythemic responses that occurred during 3 weeks at 4300 m ALT in these subjects.
PMID: 9535588

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