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result sql = Fluorescence in situ hybridization and surface markers of fine needle aspiration specimen confirm extramedullary myeloblastoma in a patient with chronic myeloid leukemia.
Fluorescence in situ hybridization and surface markers of fine needle aspiration specimen confirm extramedullary myeloblastoma in a patient with chronic myeloid leukemia.char = W;code = 87
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char = S;code = 83
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char = l;code = 108
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char = s;code = 115
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char = s;code = 115
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char = r;code = 114
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char = t;code = 116
char = e;code = 101
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char = s;code = 115
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char = i;code = 105
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char = i;code = 105
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char = e;code = 101
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char = L;code = 76
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char = T;code = 84
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char = l;code = 108
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char = t;code = 116
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char = b;code = 98
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char = t;code = 116
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char = n;code = 110
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char = t;code = 116
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char = c;code = 99
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char = e;code = 101
char = .;code = 46
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char = b;code = 98
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char = >;code = 62
result sql = We report on a patient with chronic myeloid leukemia (CML) with a rapidly growing left cervical tumor 5 months after the initial diagnosis of CML. This tumor was diagnosed as a very early manifestation of extramedullary myeloblastoma by a minimally invasive method. A fine needle aspirate (26-gauge needle) was obtained from the tumor. Morphological and cytochemical analysis of the aspirate revealed 19% undifferentiated blasts. The immunophenotype was suggestive of a myeloid differentiation of the blasts (CD33+). The CML origin of the blasts was confirmed by the detection of the bcr-abl gene rearrangement in the blasts by two-color fluorescence in situ hybridization (FISH). We conclude that fine needle aspiration in combination with immunophenotyping and FISH analysis of the aspirate is a minimally invasive and rapid diagnostic tool to confirm extramedullary manifestation in CML. To our knowledge, this is the first case of extramedullary myeloblastoma confirmed by this combined technique.
char = l;code = 108
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char = o;code = 111
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char = e;code = 101
char = s;code = 115
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = u;code = 117
char = ;code = 32
char = h;code = 104
char = y;code = 121
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char = r;code = 114
char = i;code = 105
char = d;code = 100
char = i;code = 105
char = z;code = 122
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = f;code = 102
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char = c;code = 99
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char = m;code = 109
char = a;code = 97
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char = ;code = 32
char = f;code = 102
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char = e;code = 101
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char = i;code = 105
char = m;code = 109
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char = n;code = 110
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char = c;code = 99
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char = r;code = 114
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char = e;code = 101
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char = m;code = 109
char = y;code = 121
char = e;code = 101
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char = l;code = 108
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
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char = e;code = 101
char = n;code = 110
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = h;code = 104
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char = o;code = 111
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char = c;code = 99
char = ;code = 32
char = m;code = 109
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char = e;code = 101
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char = k;code = 107
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char = m;code = 109
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char = a;code = 97
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result sql = Fluorescence in situ hybridization and surface markers of fine needle aspiration specimen confirm extramedullary myeloblastoma in a patient with chronic myeloid leukemia.
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char = o;code = 111
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result sql = We report on a patient with chronic myeloid leukemia (CML) with a rapidly growing left cervical tumor 5 months after the initial diagnosis of CML. This tumor was diagnosed as a very early manifestation of extramedullary myeloblastoma by a minimally invasive method. A fine needle aspirate (26-gauge needle) was obtained from the tumor. Morphological and cytochemical analysis of the aspirate revealed 19% undifferentiated blasts. The immunophenotype was suggestive of a myeloid differentiation of the blasts (CD33+). The CML origin of the blasts was confirmed by the detection of the bcr-abl gene rearrangement in the blasts by two-color fluorescence in situ hybridization (FISH). We conclude that fine needle aspiration in combination with immunophenotyping and FISH analysis of the aspirate is a minimally invasive and rapid diagnostic tool to confirm extramedullary manifestation in CML. To our knowledge, this is the first case of extramedullary myeloblastoma confirmed by this combined technique.
Publication: Acta Haematol. 1998 ;100(2)::91-3.
Publication Date: 1998
Study Author(s): Karthaus, M;Meran, J G;Wilkens, L;Soudah, B;Diedrich, H;Krauter, J;Ganser, A;Heil, G;
Institution: Department of Haematology and Oncology, Hannover Medical School, Germany.
Shortcut link to this study:
Publication Date: 1998
Study Author(s): Karthaus, M;Meran, J G;Wilkens, L;Soudah, B;Diedrich, H;Krauter, J;Ganser, A;Heil, G;
Institution: Department of Haematology and Oncology, Hannover Medical School, Germany.
Shortcut link to this study:
We report on a patient with chronic myeloid leukemia (CML) with a rapidly growing left cervical tumor 5 months after the initial diagnosis of CML. This tumor was diagnosed as a very early manifestation of extramedullary myeloblastoma by a minimally invasive method. A fine needle aspirate (26-gauge needle) was obtained from the tumor. Morphological and cytochemical analysis of the aspirate revealed 19% undifferentiated blasts. The immunophenotype was suggestive of a myeloid differentiation of the blasts (CD33+). The CML origin of the blasts was confirmed by the detection of the bcr-abl gene rearrangement in the blasts by two-color fluorescence in situ hybridization (FISH). We conclude that fine needle aspiration in combination with immunophenotyping and FISH analysis of the aspirate is a minimally invasive and rapid diagnostic tool to confirm extramedullary manifestation in CML. To our knowledge, this is the first case of extramedullary myeloblastoma confirmed by this combined technique.
PMID: 9792940
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